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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as Q®-C ascorbic acid)
1000 mg
1111%
Top Medical Research Studies
9
Vitamin C shows promise for UTIs
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
Strong relevance to UTI treatment
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
9.5
Vitamin C shows promise for UTIs
Antibacterial effect of vitamin C against uropathogenic E. coli in vitro and in vivo.
Relevant study on vitamin C
We explored the potential of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli (UPEC), which is a major contributor to urinary tract infections (UTIs). This research was motivated by the growing concern over antibiotic resistance, highlighting the need for safer alternatives in UTI treatments.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
Read More
7
Vitamin C enhances antibiotic effectiveness
Ascorbate and Antibiotics, at Concentrations Attainable in Urine, Can Inhibit the Growth of Resistant Strains of Cultured in Synthetic Human Urine.
Relevant antibacterial combinations explored
We investigated the impact of vitamin C, or ascorbate, on urinary tract infections caused by antibiotic-resistant bacteria. Our study focused on whether adding vitamin C could enhance the effectiveness of certain antibiotics when tested in synthetic human urine, which mimics the conditions in our bodies.
We found that while vitamin C on its own didn’t inhibit bacterial growth, when paired with antibiotics like nitrofurantoin and sulfamethoxazole, the combination showed stronger effects in synthetic urine than in standard media. This was promising, as the minimal inhibitory concentrations—meaning the lowest amounts needed to prevent bacterial growth—were below those typically found in urine.
For other antibiotics like ciprofloxacin and gentamicin, their effectiveness also improved with vitamin C in urine, which is encouraging for treating resistant strains. However, ampicillin wasn’t as affected. Importantly, the beneficial relationship we observed between vitamin C and antibiotics appeared to operate independently from the bacteria's sensitivity to oxygen or oxidative stress.
These findings support the potential for vitamin C to play a role in making certain antibiotic treatments more effective against resistant urinary tract infections. We believe these results open the door for clinical trials to explore how pairing vitamin C with antibiotics could help tackle these challenging infections more efficiently.
We found that while vitamin C on its own didn’t inhibit bacterial growth, when paired with antibiotics like nitrofurantoin and sulfamethoxazole, the combination showed stronger effects in synthetic urine than in standard media. This was promising, as the minimal inhibitory concentrations—meaning the lowest amounts needed to prevent bacterial growth—were below those typically found in urine.
For other antibiotics like ciprofloxacin and gentamicin, their effectiveness also improved with vitamin C in urine, which is encouraging for treating resistant strains. However, ampicillin wasn’t as affected. Importantly, the beneficial relationship we observed between vitamin C and antibiotics appeared to operate independently from the bacteria's sensitivity to oxygen or oxidative stress.
These findings support the potential for vitamin C to play a role in making certain antibiotic treatments more effective against resistant urinary tract infections. We believe these results open the door for clinical trials to explore how pairing vitamin C with antibiotics could help tackle these challenging infections more efficiently.
Read More
Most Useful Reviews
7.5
Helpful for colds
For colds and acute respiratory viral infections, vitamin C is quite beneficial. The dosage is appropriate.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
9.5
Vitamin C shows promise for UTIs
Antibacterial effect of vitamin C against uropathogenic E. coli in vitro and in vivo.
Relevant study on vitamin C
We explored the potential of vitamin C as an antibacterial and anti-biofilm agent against uropathogenic E. coli (UPEC), which is a major contributor to urinary tract infections (UTIs). This research was motivated by the growing concern over antibiotic resistance, highlighting the need for safer alternatives in UTI treatments.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
To understand vitamin C's effectiveness, we conducted both in vitro and in vivo assessments. We tested the impact of vitamin C on E. coli isolates and used a rat model to evaluate its therapeutic effects. The results showed that a vitamin C concentration of 1.25 mg/ml inhibited the growth of 70% of the bacterial isolates. Additionally, it demonstrated a strong synergy with several antibiotics, enhancing their effectiveness without any harmful interactions.
Interestingly, vitamin C also served as an effective anti-biofilm agent. We found that a lower concentration of 0.312 mg/ml was enough to convert 43 biofilm-producing isolates into non-biofilm producers, indicating its potential to disrupt bacterial colonies that are often resistant to treatment. In the rat model, vitamin C provided a rapid curative effect similar to typical antibiotics and when used alongside drugs such as nitrofurantoin, it yielded even better results.
Overall, our findings suggest that vitamin C could serve as a beneficial treatment for UTIs, either on its own or in combination with antibiotics, presenting a promising alternative in the fight against antibiotic-resistant infections.
Read More
9
Vitamin C shows promise for UTIs
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
Strong relevance to UTI treatment
We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.
Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.
Read More
8
Oral vitamin C aids UTI symptoms
Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial.
Vitamin C's impact is unclear
We conducted a study focusing on how an oral preparation that includes vitamin C, along with other compounds, might help alleviate urinary tract infection (UTI) symptoms. Through a randomized crossover trial involving participants of reproductive age with recurrent UTIs, we compared two groups: one that received a combination treatment containing vitamin C and another that received a control treatment with various other ingredients.
Over a period of six months, we evaluated participants for changes in urinary and sexual symptoms using standardized assessment tools. Our approach allowed us to observe how effective the treatment was at different intervals.
The results indicated that the combination of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C could lead to improvements in both urinary and sexual function symptoms in study participants. This suggests that vitamin C, when used alongside other compounds, may play a beneficial role in managing symptoms of UTIs.
However, it’s important to note that because vitamin C was part of a multi-ingredient approach, isolating its specific impact remains a challenge. Nonetheless, our findings encourage further exploration into vitamin C's role within such combinations for patients dealing with recurrent UTIs.
Over a period of six months, we evaluated participants for changes in urinary and sexual symptoms using standardized assessment tools. Our approach allowed us to observe how effective the treatment was at different intervals.
The results indicated that the combination of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C could lead to improvements in both urinary and sexual function symptoms in study participants. This suggests that vitamin C, when used alongside other compounds, may play a beneficial role in managing symptoms of UTIs.
However, it’s important to note that because vitamin C was part of a multi-ingredient approach, isolating its specific impact remains a challenge. Nonetheless, our findings encourage further exploration into vitamin C's role within such combinations for patients dealing with recurrent UTIs.
Read More
8
Vitamin C's potential role in UTIs
Intravesical acetic acid in combination with prophylactic methenamine and ascorbic acid to decrease the incidence of recurrent urinary tract infections associated with intermittent urinary self-catherization: A case report.
Complex treatment combination challenges
We explored the effectiveness of combining vitamin C, specifically oral methenamine hippurate and ascorbic acid, with acetic acid irrigation in preventing urinary tract infections (UTIs) in a post-menopausal woman living with multiple sclerosis. The patient, a retired radiologist, self-administered acetic acid during her routine intermittent bladder self-catheterization. This addition aimed to enhance the antibacterial properties of vitamin C while supporting the body's natural defenses against UTIs.
Through this approach, we aimed to determine any improved efficacy in preventing recurrent UTIs. While there was a notable improvement in the overall treatment outcomes, it’s important to acknowledge that the study involved a combination of treatments, making it challenging to isolate the specific impact of vitamin C alone. This complexity does not undermine its potential benefits but does suggest that more research is needed to fully understand how vitamin C functions in preventing UTIs when combined with other therapies.
Through this approach, we aimed to determine any improved efficacy in preventing recurrent UTIs. While there was a notable improvement in the overall treatment outcomes, it’s important to acknowledge that the study involved a combination of treatments, making it challenging to isolate the specific impact of vitamin C alone. This complexity does not undermine its potential benefits but does suggest that more research is needed to fully understand how vitamin C functions in preventing UTIs when combined with other therapies.
Read More
8
Vitamin C may support UTI management
Effectiveness of a Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study.
Combined treatment effectiveness observed
We explored how a combination of cranberries, Lactobacillus rhamnosus, and vitamin C could help manage recurrent urinary tract infections (UTIs) in women. In this study, 42 women with a history of UTIs took 120mg of cranberries, 1 billion heat-killed L. rhamnosus SGL06, and 750mg of vitamin C three times a day for 20 days each month, repeating this for three months.
After three and six months of follow-up, we found that approximately 72% and 61% of the participants, respectively, reported no symptoms of UTIs and had negative urinalysis results. While vitamin C was part of the combination, the study primarily assessed the effects of all three components working together, which complicates determining vitamin C's specific impact.
Overall, the administration of this combination may represent a promising and safe option for women facing recurrent UTIs, suggesting that these nutritional supplements could provide benefits beyond traditional antibiotic treatments.
After three and six months of follow-up, we found that approximately 72% and 61% of the participants, respectively, reported no symptoms of UTIs and had negative urinalysis results. While vitamin C was part of the combination, the study primarily assessed the effects of all three components working together, which complicates determining vitamin C's specific impact.
Overall, the administration of this combination may represent a promising and safe option for women facing recurrent UTIs, suggesting that these nutritional supplements could provide benefits beyond traditional antibiotic treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
Helpful for colds
For colds and acute respiratory viral infections, vitamin C is quite beneficial. The dosage is appropriate.
